scMEGA: Single-cell Multiomic Enhancer-based Gene regulAtory network inference

You can install scMEGA via below commands:

# Install devtools
if (!requireNamespace("devtools", quietly = TRUE))
    install.packages("devtools")
    
# Install supported Seurat v5 and Signac releases
install.packages(c("Seurat", "SeuratObject", "Signac"))
stopifnot(
    packageVersion("Seurat") >= "5.0.0",
    packageVersion("SeuratObject") >= "5.0.0"
)
    
# Install scMEGA
devtools::install_github("CostaLab/scMEGA")

We provided the following tutorials to show how to use scMEGA to build GRN by using single-cell multiomics/multimodal data:

• Myofibroblasts differentiation

• Cardiomyocytes remodelling

• CD4 T cells activcation using 10X multiome data

Please consider citing our paper if you used scMEGA:

@article{li2023scmega,
  title={scMEGA: single-cell multi-omic enhancer-based gene regulatory network inference},
  author={Li, Zhijian and Nagai, James S and Kuppe, Christoph and Kramann, Rafael and Costa, Ivan G},
  journal={Bioinformatics Advances},
  volume={3},
  number={1},
  pages={vbad003},
  year={2023},
  publisher={Oxford University Press}
}