diff --git a/cassandra/connection.py b/cassandra/connection.py
index ac2578a16c..6df8c20527 100644
--- a/cassandra/connection.py
+++ b/cassandra/connection.py
@@ -485,6 +485,8 @@ def __repr__(self):
 
 
 class _Frame(object):
+    __slots__ = ('version', 'flags', 'stream', 'opcode', 'body_offset', 'end_pos')
+
     def __init__(self, version, flags, stream, opcode, body_offset, end_pos):
         self.version = version
         self.flags = flags